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Thread: How can you have a baby who doesn't carry a gene that a parent might have?

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    tWebber Ana Dragule's Avatar
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    How can you have a baby who doesn't carry a gene that a parent might have?

    How can you have a baby who doesn't carry a gene that a parent might have?
    I am become death...

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    tWebber thewriteranon's Avatar
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    Quote Originally Posted by Ana Dragule View Post
    How can you have a baby who doesn't carry a gene that a parent might have?
    Genes can remain recessive over generations. Parents can have babies who show a trait that is found in a grandparent or blood uncle or aunt or whatever. Genes are a complicated mix of dominant and recessive and even sometimes two dominants fighting for display.

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    tWebber sylas's Avatar
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    Also, the genes of your children are half from you, half from your partner. So for any child of yours, they only have a copy of half your genes.

  4. Amen Teallaura amen'd this post.
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    tWebber Ana Dragule's Avatar
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    I was thinking like a cancer gene.
    I am become death...

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    tWebber Teallaura's Avatar
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    Unless both parents carry a trait it's very easy for a given child to not have that trait. Even if both parents carry it, it may not be expressed in a given child. The only times a trait is certain to express is if both parents have it and neither has a recessive gene for it - or both only have recessive genes for it.

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    tWebber Teallaura's Avatar
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    Quote Originally Posted by Ana Dragule View Post
    I was thinking like a cancer gene.
    Cancer has more to do with damage to gene than a trait that causes it.

  8. Amen DesertBerean, Chrawnus amen'd this post.
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    Professor Catholicity's Avatar
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    There is one gene that we know of that's passed BRCA1 and 2 from mother to child which is a cause of breast cancer BUT Mothers don't necessarily pass it. Even in situations where we might see children with Tay-Sachs disease (such as both parents have the gene) realistically its only a one in four chance that they will have a child with Tay-Sachs. Diseases where there is a specific inherited "mutant genetic cause" are actually quite rare and not all children will inherit them . Its not like eye color by any means. Although when you go and look at the specifics of eye color, you can have multiple generations of parents with one color of eyes and then bam, end up with several children who have different color eyes due to either genetic alterations or intermarrying with a family that has genes for the expression of other eye color.
    A happy family is but an earlier heaven.
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  10. Amen Teallaura, DesertBerean amen'd this post.
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    tWebber Ana Dragule's Avatar
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    I am referring to a very specific situation in which there is a family history of a rare cancer and subsequent cancers outside of an affected region. This primary cancer, on the last website I read, has a 40 chance of being inherited. Given the family history...
    I am become death...

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    Professor Catholicity's Avatar
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    Quote Originally Posted by Ana Dragule View Post
    I am referring to a very specific situation in which there is a family history of a rare cancer and subsequent cancers outside of an affected region. This primary cancer, on the last website I read, has a 40 chance of being inherited. Given the family history...
    I think the best comparison would be the BRCA gene. If both genes are inherited then the female child has a certain percentage of getting breast or ovarian cancer (its rather high in comparison to general population) However even if both parents are carriers its also possible that a child could 1) not recieve the gene markers, or recieve only 1 genetic marker or receive both genetic markers and still never get the disease because something something else has caused the genetic markers to "turn off" or not express at all. Genetic expression is never totally finite when it comes to inherited diseases it seems It appears to take two copies of a gene in the correct sequencing and they must both be of a dominant profile appearing in all chromosomal strains.
    A happy family is but an earlier heaven.
    George Bernard Shaw

  13. Amen Teallaura amen'd this post.
  14. #10
    tWebber Ana Dragule's Avatar
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    Quote Originally Posted by Catholicity View Post
    I think the best comparison would be the BRCA gene. If both genes are inherited then the female child has a certain percentage of getting breast or ovarian cancer (its rather high in comparison to general population) However even if both parents are carriers its also possible that a child could 1) not recieve the gene markers, or recieve only 1 genetic marker or receive both genetic markers and still never get the disease because something something else has caused the genetic markers to "turn off" or not express at all. Genetic expression is never totally finite when it comes to inherited diseases it seems It appears to take two copies of a gene in the correct sequencing and they must both be of a dominant profile appearing in all chromosomal strains.
    As I understand, RB is an autosomal dominant gene with an 80-90% penetration rate for RB or other cancers developing. It resides on neither the x nor the y chromosome.
    I am become death...

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