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Yet another beneficial mutation in humans uncovered
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Yet another beneficial mutation in humans uncovered
I'm always still in trouble again
"You're by far the worst poster on TWeb" and "TWeb's biggest liar" --starlight (the guy who says Stalin was a right-winger)
"Overall I would rate the withdrawal from Afghanistan as by far the best thing Biden's done" --Starlight
"Of course, human life begins at fertilization that’s not the argument." --TassmanTags: None
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So I must take my own water if I ever go there. Got itWe are therefore Christ's ambassadors, as though God were making his appeal through us. We implore on Christ's behalf: 'Be reconciled to God!!'- 2 Corinthians 5:20.
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Originally posted by Bisto View PostSo I must take my own water if I ever go there. Got it
I'm always still in trouble again
"You're by far the worst poster on TWeb" and "TWeb's biggest liar" --starlight (the guy who says Stalin was a right-winger)
"Overall I would rate the withdrawal from Afghanistan as by far the best thing Biden's done" --Starlight
"Of course, human life begins at fertilization that’s not the argument." --Tassman
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Originally posted by rogue06 View Post
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Originally posted by Sparko View PostIs it evolution or selective breeding? is it really a mutation to something new, or a natural variation that just got concentrated in this population because anyone without it dies?
I'm always still in trouble again
"You're by far the worst poster on TWeb" and "TWeb's biggest liar" --starlight (the guy who says Stalin was a right-winger)
"Overall I would rate the withdrawal from Afghanistan as by far the best thing Biden's done" --Starlight
"Of course, human life begins at fertilization that’s not the argument." --Tassman
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Originally posted by Sparko View PostIs it evolution or selective breeding? is it really a mutation to something new, or a natural variation that just got concentrated in this population because anyone without it dies?Originally posted by rogue06 View PostIt is a mutation that is being selected for due to environmental pressure.Originally posted by TheLurch View PostWhich, to be clear, is evolution.We are therefore Christ's ambassadors, as though God were making his appeal through us. We implore on Christ's behalf: 'Be reconciled to God!!'- 2 Corinthians 5:20.
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Originally posted by Bisto View PostI get the distinct impression that the three of you just said the same thing in different ways.
I'm always still in trouble again
"You're by far the worst poster on TWeb" and "TWeb's biggest liar" --starlight (the guy who says Stalin was a right-winger)
"Overall I would rate the withdrawal from Afghanistan as by far the best thing Biden's done" --Starlight
"Of course, human life begins at fertilization that’s not the argument." --Tassman
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Originally posted by rogue06 View PostIt is a mutation that is being selected for due to environmental pressure.
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Originally posted by Sparko View Postwhy is it a mutation and not a natural variation. If a group starts killing off everyone who is not blond, eventually all the nonblonde genes will be bred out and the population will all breed blonde.
I'm always still in trouble again
"You're by far the worst poster on TWeb" and "TWeb's biggest liar" --starlight (the guy who says Stalin was a right-winger)
"Overall I would rate the withdrawal from Afghanistan as by far the best thing Biden's done" --Starlight
"Of course, human life begins at fertilization that’s not the argument." --Tassman
Comment
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Originally posted by Bisto View PostI get the distinct impression that the three of you just said the same thing in different ways.
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Originally posted by Sparko View Postwhy is it a mutation and not a natural variation. If a group starts killing off everyone who is not blond, eventually all the nonblonde genes will be bred out and the population will all breed blonde."Any sufficiently advanced stupidity is indistinguishable from trolling."
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Here's a short list of some of the beneficial mutations in humans that scientists have discovered known to have effected humans as a whole or particular groups that I came up with (I'm sure there are are many I missed):
1.2. A similar though different mutation has also been identified among native people living at high altitudes in the Andes. In the South American case the adaptation involves making more red blood cells, which transport oxygen to the body's tissues. For example, native people in the Peruvian Andes have higher red blood cell counts than their countrymen living at sea level.
There is yet another totally different mutation among the people native to the Ethiopian highlands that allows them to survive better at high altitude.
3. Another well known example of a beneficial mutation are those that provide lactase persistence (brought up by The Lurch in the post above). An allele conferring lactase persistence has evolved at least seven different times in the last 7000 years among pastoralist groups allowing adult humans to drink milk. This provides them with another source of food to consume that those who are lactate intolerant can not use. That would definitely come in handy during periods of decreased food supply.
4. Similar are mutations of the ADH enzymes that allow for the consumption of alcoholic beverages. While alcohol consumption (more specifically its over-consumption) is the cause of many societal ills, it provided an important benefit in early cultures. Alcohol is rich in energy, portable and is far less susceptible to spoilage than the materials that they were made from like grains in the case of beer. Moreover, it has a far lower pathogenic load than water in a pre-modern environments.
All of this means that the ability to drink alcohol allowed people to get nutritional value from food stuffs subject to spoiling or more difficult to transport. Again this is a distinct advantage over those who had no tolerance for alcohol in the time of food shortages.
5. A mutation in the FADS gene cluster that scientists thought took place some 85,000 years ago allowed humans to manufacture long chain polyunsaturated fatty acids from plant fats. This meant that early humans no longer had to rely on just one food source, fish, for brain growth and development and allowed them to be able to leave the region.
6.7. Then there is ccr5-Δ32 which changes cell surface receptors and confers a significant resistance to infection by HIV-1 and may also confer some resistance to small pox and some plagues. Interestingly it does cause a higher susceptibility to West Nile.
8. Another example of beneficial mutations are some of the family members from the village of Limone Sul Garda in northern Italy have a mutation which gives them better tolerance of HDL serum cholesterol. This mutation was traced to a single common ancestor living in the 1700's, but has now spread to dozens of descendants and as a result this family has no history of heart attacks in spite of their high-risk dietary habits.
Genetic samples from this family are now being tested for potential treatment of patients of heart disease.
9.Unbreakable10. One of the best known mutations is the apoA-I Milano allele mutation that has effected the apolipoprotein A1 protein found in human High-density lipoprotein (HDL), the lipoprotein particle that carries cholesterol from tissues to the liver and is associated with significantly reducing cardiovascular disease (specifically clogged arteries, heart attack, and stroke). This particular mutation was first documented in 1980 among some villagers living in northern Italy, all of who are descendants of a particular 18th century man named Giovanni Pomarelli. Synethetic versions have been manufactured and are making their way to market.
11.12. A little over a year ago a paper was released in Science which explains why the Inuits (formerly referred to as "Eskimos"), despite a diet that is heavily dependent upon fatty meat and fish (a diet which has long been associated with an increased risk in heart attacks and stroke) have a relatively low rate of cardiovascular disease. It appears that they have adaptive genetic mutations that allow them to better process the fats that they eat. These mutations occurred within a cluster of genes that direct construction of enzymes called fatty acid desaturases (FADS).
13. And the one that gets evolution deniers all worked up are the various mutations that confer resistance to malaria. Nearly everyone is aware of the sickle cell allele which confers resistance to malarial infections if you carry one copy of the allele but causes sickle cell anemia if you carry two copies. It's a good example of balancing selection. And even those with sickle cell anemia are considerably more likely to survive long enough to reproduce than those suffering from malaria.
What many are not aware of is that there are other alleles which confer resistance. The HbC variant for hemoglobin confers roughly a 30% reduction in risk for malarial infection if you have one copy but a 93% risk reduction if you have two copies. The anemia resulting from the double copy of this gene variant is very mild in contrast to the debilitating effects of sickle cell.
Then there is the various types of Thalassemia. While they all have negative effects (bone deformities, and cardiovascular illness like anemia) it also confers a degree of protection against malaria (specifically, malaria caused by the protozoan parasite Plasmodium falciparum) and those with β-thalassemia apparently have some protection against coronary heart disease.
Finally, a single genetic mutation protects some African children from the deadly symptoms of malaria. The mutation occurs in the gene NOS2 that encodes an enzyme to produce the gas nitric oxide -- something that is present throughout the human body. The mutation is a polymorphism, a single letter change in DNA. It causes cells to ramp up production of the gas, which is thought to protect people against malaria.
Children in Tanzania and Kenya who have the mutation are much less likely to develop the disease than children who do not, with one study discovering that those with the mutation living in Tanzania were nearly 90% less likely to develop severe malaria than individuals without the mutation.
I'm always still in trouble again
"You're by far the worst poster on TWeb" and "TWeb's biggest liar" --starlight (the guy who says Stalin was a right-winger)
"Overall I would rate the withdrawal from Afghanistan as by far the best thing Biden's done" --Starlight
"Of course, human life begins at fertilization that’s not the argument." --Tassman
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Originally posted by shunyadragon View PostNo 'selective breeding' describes human influence improve species, sub-species, and varieties to increase the benefit for human consumption and use. Evolution and natural selection is the response species to evolve, change and diversify into new species in response to natural pressures, and opportunities for expansion into new environments.We are therefore Christ's ambassadors, as though God were making his appeal through us. We implore on Christ's behalf: 'Be reconciled to God!!'- 2 Corinthians 5:20.
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Originally posted by rogue06 View Post3. Another well known example of a beneficial mutation are those that provide lactase persistence (brought up by The Lurch in the post above). An allele conferring lactase persistence has evolved at least seven different times in the last 7000 years among pastoralist groups allowing adult humans to drink milk. This provides them with another source of food to consume that those who are lactate intolerant can not use. That would definitely come in handy during periods of decreased food supply."Any sufficiently advanced stupidity is indistinguishable from trolling."
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